ras gene Amplification and malignant transformation.
نویسندگان
چکیده
منابع مشابه
No evidence for ErbB4 gene amplification in malignant melanoma.
Malignant melanoma (MM) represents the most severe skin cancer (1). Somatic ErbB4 gene mutations have been identified in 19% of individuals with MM (2). These mutations result in hyperactivation of the ErbB4 receptor (2, 3). This finding indicates a pivotal role of the ErbB4 receptor tyrosine kinase (RTK) in the tumourigenesis of MM. However, oncogenic receptor activation of ErbB RTKs in human ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1985
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.5.10.2836